Since 2014, when Red Glead Discovery acquired the peptide company Pepticon, we provide customized synthesis of exclusive and complex peptides of the highest quality and purity to industry and academia.

 
  • Synthesis of peptides using solid phase technology
  • Purification by preparative HPLC
  • Solution phase methods employed as complementary approaches
  • Up to 50–60 amino acid single chain peptides. Deliveries of longer peptides possible using chemical ligation techniques.
  • Non-natural amino acids & other building blocks on a custom basis

Our expertise enables informed design of new cost-effective synthetic routes for peptides, including selection of adequate resin, introduction of chemical modifications and effective ways of cyclization, for example.

We also offer design of peptides aimed at improving biological activity & profile, stability as well as physicochemical and pharmacokinetic properties.

Peptide Analysis

Quality control confirming chemical identity, amino acid sequence and amino-specific modifications is routinely performed on our produced peptides using HPLC, LC-MS, LC-MS/MS and NMR spectroscopy. Delivered peptide material is accompanied by a Certificate of Analysis. Additional documentation can be provided if requested by the client.

Analytical capabilities at RGD

  • Purity by HPLC-UV
  • Molecular mass and amino acid sequence by MS/MS
  • Purity, peptide content and acetate content by 1D 1H NMR
  • Amino acid sequence and/or 3D structure by 1H/13C/15N NMR
  • Impurity ID by LC-MS/MS and NMR
  • In-house NMR method for detection of small molecule impurities in peptide samples down to <0.1%. Quantitation and structural elucidation feasible

Examples of peptide analyses performed by trusted partners:

  • Non-chiral & chiral amino acid analysis, peptide content (elemental analysis)
 

Cases & References

“Red Glead Discovery is the only company that has managed to produce our glycopeptide in required amounts and without failure.”

  • Continuous support with high-quality synthesis of peptide impurities to established pharma and CMO companies, incl. synthesis and incorporation of novel amino acid derivatives
  • Supporting spin-out company effort by academic group by delivering synthesis of peptide >50 amino acids long with improved solubility through small modifications without compromising biological activity.
  • Synthesis of peptides with multiple and selectively oxidized disulfide bridges
  • Providing structural data by NMR for US-based peptide company showing equivalence between synthetic peptides and peptide produced by bacteria
 

Labs & Technologies

Instruments

  • Two Biotage® Initiator+ Alstra™ fully automated microwave peptide synthesizers
  • Activo-P11 heated peptide synthesizer

Purification capabilities

  • Several preparative HPLC-UV systems
  • Ion exchange chromatography

Modification capabilities

  • Amino acid substitutions, chemically modified building blocks and amino acid derivatives
  • Attachment of ligands (e.g. chromophores, affinity ligands, PEG units), conjugation of peptides to proteins and antibodies
  • Incorporation of stable isotopes
  • Preparation of precursors amenable for labelling with radioactive isotopes
 

Contact

If you would like to know more about how to exploit our peptide chemistry capabilities, please contact us at:

pepticon@redglead.com

Or visit us in

Building 403 at Medicon Village in Lund, Sweden

We would be happy to provide you a quote for the preparation and delivery of your peptide.

 

Contact

+46 46 460 12 90
+46 46 460 12 91
+46 46 460 12 92
info@redglead.com

Visiting address

Medicon Village
Building 403
Scheelevägen 2
223 63 Lund, Sweden

Shipping address

Red Glead Discovery AB
Medicon Village
Scheelevägen 8
223 63 Lund, Sweden

Postal address

Medicon Village
SE-223 81 Lund, Sweden