Publications

Monteiro, H.; Santos, F.; Paiva A.; Duarte, A. R. C.; Ferreira, R. J. Molecular Dynamics Studies of Therapeutic Liquid Mixtures and Their Binding to Mycobacteria. Front. Pharmacol. 2021,12:626735.
https://doi:10.3389/fphar.2021.626735

Lehmann, F.; Wennerberg, J. Evolution of Nitrogen-Based Alkylating Anticancer Agents. Processes 2021, 9, 377. https://doi.org/10.3390/pr9020377

Mannerstedt, K.; Mishra, N. M.; Engholm, E.; Lundh, M.; Madsen, C. S.; Pedersen, P. J.; Le-Huu, P.; Pedersen, S. L.; Buch-Månson, N.; Borgström, B.; Brimert, T.; Fink, L. N.; Fosgerau, K.; Vrang, N.; Jensen, K. J. An Aldehyde Responsive, Cleavable Linker for Glucose Responsive Insulins. Chemistry, 2021, 1-12. https://doi.org/10.1002/chem.202004878

Lehmann, F.; Wennerberg, J. Melflufen: A Journey from Discovery to Multi-Kilogram Production in Complete Accounts of Integrated Drug Discovery and Development: Recent Examples from the Pharmaceutical Industry Volume 3, Chapter 5 pp 157-177, 2020. https://doi:10.1021/bk-2020-1369.ch005

Castiglia, F.; Zevolini, F.; Riolo, G.; Brunetti J, De Lazzari, A:, Moretto, A.; Manetto, G.; Fragai, M.; Algotsson, J.; Evenäs, J.; Bracci, L.; Pini, A.; Falciani, C. NMR Study of the Secondary Structure and Biopharmaceutical Formulation of an Active Branched Antimicrobial Peptide. Molecules 2019, 24(23), 4290-4302.
https://doi.org/10.3390/molecules24234290

Zetterberg, F.; Peterson, K.; Johnsson, R.; Brimert, T.; Håkansson, M.; Logan. D.; Leffler, H.; Nilsson, U. Monosaccharide Derivatives with Low Nanomolecular Lectin
Affinity and High Selectivity Based on Combined Fluorine-Amide, Phenyl-Arginine,
Sulfur-π, and Halogen Bond Interactions. ChemMedChem. 2018;13(2):133–137.
https://doi.org/10.1002/cmdc.201700744

Kukic, P.; Lundström, P.; Camilloni, C.; Evenäs, J.; Akke, M.; Vendruscolo, M.
Structural Insights into the Calcium-Mediated Allosteric Transition in the C-Terminal Domain of Calmodulin from Nuclear Magnetic Resonance Measurement. Biochemistry 2016 Jan 12;55(1):19-28. https://doi.org/10.1021/acs.biochem.5b00961

Edfeldt, F.; Evenäs, J.; Lepistö, M.; Ward, A.; Petersen, J.; Wissler, L.; Rohman, M.; Sivars, U.; Svensson, K:, Perry, M.; Feierberg, I:, Zhou, X.; Hansson, T.; Narjes, F. Identification of indole inhibitors of human hematopoietic prostaglandin D2 synthase (hH-PGDS). Bioorg Med Chem Lett. 2015 15;25(12):2496-2500.
https://doi.org/10.1016/j.bmcl.2015.04.065

Evenäs, J.; Edfeldt, F.; Lepistö, M.; Svitacheva, N.; Synnergren, A.; Lundquist, B.; Gränse, M.; Rönnholm, A.; Varga, M.; Wright, J.; Wei, M.; Yue, S.; Wang, J.; Li, C,; Li, X.; Chen, G:, Liao, Y.; Lv, G.; Tjörnebo, A.; Narjes, F. HTS followed by NMR based counterscreening. Discovery and optimization of pyrimidones as reversible and competitive inhibitors of xanthine oxidase. Bioorg & Med Chem Lett. 2014, 24(5), 1315–1321. https://doi.org/10.1016/j.bmcl.2014.01.050

Lorem ipsum

RG100204, A Novel Aquaporin-9 Inhibitor, Reduces Septic Cardiomyopathy and Multiple Organ Failure in Murine Sepsis

Mohammad S, O'Riordan CE, Verra C, Aimaretti E, Alves GF, Dreisch K, Evenäs J, Gena P, Tesse A, Rützler M, Collino M, Calamita G, Thiemermann C.
Front Immunol. 2022 Jun 14;13:900906.

Sialic Acid Derivatives Inhibit SiaT Transporters and Delay Bacterial Growth

Bozzola T, Scalise M, Larsson CU, Newton-Vesty MC, Rovegno C, Mitra A, Cramer J, Wahlgren WY, Radhakrishnan Santhakumari P, Johnsson RE, Schwardt O, Ernst B, Friemann R, Dobson RCJ, Indiveri C, Schelin J, Nilsson UJ, Ellervik U.
ACS Chem Biol. 2022 Jul 15;17(7):1890-1900.

Characterization of the Aquaporin-9 Inhibitor RG100204 In Vitro and in db/db Mice

Massaro A, Timpka S, Reimer MK, Kjellbom P, Beitz E, Johanson U, Rützler M, Calamita G.
Cells, 11(19), 3118.

Discovery and Optimization of the First Highly Effective and Orally Available Galectin-3 Inhibitors for Treatment of Fibrotic Disease.

Zetterberg FR, MacKinnon A, Brimert T, Gravelle L, Johnsson RE, Kahl-Knutson B, Leffler H, Nilsson UJ, Pedersen A, Peterson K, Roper JA, Schambye H, Slack RJ, Tantawi S.
J Med Chem. 2022 Oct 13;65(19):12626-12638.

A practical and environmentally friendly protocol forsynthesis of α-deuterated carboxylic acids

Wennerberg J, & Dreisch, K.
J Labelled Comp Radiopharm. 2023 Apr-May;66(4-6).

Molecular Dynamics Studies of Therapeutic Liquid Mixtures and Their Binding to Mycobacteria

Monteiro H, Santos F, Paiva A, Duarte ARC, Ferreira RJ.
Front Pharmacol. 2021 Apr 20;12:626735.

Evolution of Nitrogen-Based Alkylating Anticancer Agents

Lehmann F, Wennerberg J.
Processes 2021, 9, 377

An Aldehyde Responsive, Cleavable Linker for Glucose Responsive Insulins

Mannerstedt K, Mishra NK, Engholm E, Lundh M, Madsen CS, Pedersen PJ, Le-Huu P, Pedersen SL, Buch-Månson N, Borgström B, Brimert T, Fink LN, Fosgerau K, Vrang N, Jensen KJ.
Chemistry. 2021 Feb 10;27(9):3166-3176.

Melflufen: A Journey from Discovery to Multi-Kilogram Production

Lehmann F, Wennerberg J.
Complete Accounts of Integrated Drug Discovery and Development: Recent Examples from the Pharmaceutical Industry Volume 3, Chapter 5 pp 157-177, 2020

NMR Study of the Secondary Structure and Biopharmaceutical Formulation of an Active Branched Antimicrobial Peptide

Castiglia F, Zevolini F, Riolo G, Brunetti J, De Lazzari A, Moretto A, Manetto G, Fragai M, Algotsson J, Evenäs J, Bracci L, Pini A, Falciani C.
Molecules. 2019 Nov 25;24(23):4290.

Monosaccharide Derivatives with Low Nanomolecular Lectin Affinity and High Selectivity Based on Combined Fluorine-Amide, Phenyl-Arginine, Sulfur-π, and Halogen Bond Interactions

Zetterberg FR, Peterson K, Johnsson RE, Brimert T, Håkansson M, Logan DT, Leffler H, Nilsson UJ.
ChemMedChem. 2018 Jan 22;13(2):133-137.

Structural Insights into the Calcium-Mediated Allosteric Transition in the C-Terminal Domain of Calmodulin from Nuclear Magnetic Resonance Measurement

Kukic P, Lundström P, Camilloni C, Evenäs J, Akke M, Vendruscolo M.
Biochemistry. 2016 Jan 12;55(1):19-28.

Identification of indole inhibitors of human hematopoietic prostaglandin D2 synthase (hH-PGDS)

Edfeldt F, Evenäs J, Lepistö M, Ward A, Petersen J, Wissler L, Rohman M, Sivars U, Svensson K, Perry M, Feierberg I, Zhou XH, Hansson T, Narjes F.
Bioorg Med Chem Lett. 2015 Jun 15;25(12):2496-500.

HTS followed by NMR based counterscreening. Discovery and optimization of pyrimidones as reversible and competitive inhibitors of xanthine oxidase

Evenäs J, Edfeldt F, Lepistö M, Svitacheva N, Synnergren A, Lundquist B, Gränse M, Rönnholm A, Varga M, Wright J, Wei M, Yue S, Wang J, Li C, Li X, Chen G, Liao Y, Lv G, Tjörnebo A, Narjes F.
Bioorg Med Chem Lett. 2014 Mar 1;24(5):1315-21.