Publications

Monteiro, H.; Santos, F.; Paiva A.; Duarte, A. R. C.; Ferreira, R. J. Molecular Dynamics Studies of Therapeutic Liquid Mixtures and Their Binding to Mycobacteria. Front. Pharmacol. 2021,12:626735.
https://doi:10.3389/fphar.2021.626735

Lehmann, F.; Wennerberg, J. Evolution of Nitrogen-Based Alkylating Anticancer Agents. Processes 2021, 9, 377. https://doi.org/10.3390/pr9020377

Mannerstedt, K.; Mishra, N. M.; Engholm, E.; Lundh, M.; Madsen, C. S.; Pedersen, P. J.; Le-Huu, P.; Pedersen, S. L.; Buch-Månson, N.; Borgström, B.; Brimert, T.; Fink, L. N.; Fosgerau, K.; Vrang, N.; Jensen, K. J. An Aldehyde Responsive, Cleavable Linker for Glucose Responsive Insulins. Chemistry2021, 1-12. https://doi.org/10.1002/chem.202004878

Lehmann, F.; Wennerberg, J. Melflufen: A Journey from Discovery to Multi-Kilogram Production in Complete Accounts of Integrated Drug Discovery and Development: Recent Examples from the Pharmaceutical Industry Volume 3Chapter 5 pp 157-177, 2020https://doi:10.1021/bk-2020-1369.ch005

Castiglia, F.; Zevolini, F.; Riolo, G.; Brunetti J, De Lazzari, A:, Moretto, A.; Manetto, G.; Fragai, M.; Algotsson, J.; Evenäs, J.; Bracci, L.; Pini, A.; Falciani, C. NMR Study of the Secondary Structure and Biopharmaceutical Formulation of an Active Branched Antimicrobial Peptide. Molecules 2019, 24(23), 4290-4302.
https://doi.org/10.3390/molecules24234290

Zetterberg, F.; Peterson, K.; Johnsson, R.; Brimert, T.; Håkansson, M.; Logan. D.; Leffler, H.; Nilsson, U. Monosaccharide Derivatives with Low Nanomolecular Lectin
Affinity and High Selectivity Based on Combined Fluorine-Amide, Phenyl-Arginine,
Sulfur-π, and Halogen Bond Interactions. ChemMedChem2018;13(2):133–137.
https://doi.org/10.1002/cmdc.201700744

Kukic, P.; Lundström, P.; Camilloni, C.; Evenäs, J.; Akke, M.; Vendruscolo, M.
Structural Insights into the Calcium-Mediated Allosteric Transition in the C-Terminal Domain of Calmodulin from Nuclear Magnetic Resonance Measurement. Biochemistry 2016 Jan 12;55(1):19-28. https://doi.org/10.1021/acs.biochem.5b00961

Edfeldt, F.; Evenäs, J.; Lepistö, M.; Ward, A.; Petersen, J.; Wissler, L.; Rohman, M.; Sivars, U.; Svensson, K:, Perry, M.; Feierberg, I:, Zhou, X.; Hansson, T.; Narjes, F. Identification of indole inhibitors of human hematopoietic prostaglandin D2 synthase (hH-PGDS). Bioorg Med Chem Lett. 2015 15;25(12):2496-2500.
https://doi.org/10.1016/j.bmcl.2015.04.065

Evenäs, J.; Edfeldt, F.; Lepistö, M.; Svitacheva, N.; Synnergren, A.; Lundquist, B.; Gränse, M.; Rönnholm, A.; Varga, M.; Wright, J.; Wei, M.; Yue, S.; Wang, J.; Li, C,; Li, X.; Chen, G:, Liao, Y.; Lv, G.; Tjörnebo, A.; Narjes, F. HTS followed by NMR based counterscreening. Discovery and optimization of pyrimidones as reversible and competitive inhibitors of xanthine oxidase. Bioorg & Med Chem Lett. 2014, 24(5), 1315–1321. https://doi.org/10.1016/j.bmcl.2014.01.050

Lorem ipsum

Molecular Dynamics Studies of Therapeutic Liquid Mixtures and Their Binding to Mycobacteria

Monteiro, H.; Santos, F.; Paiva A.; Duarte, A. R. C.; Ferreira, R. J.
Front. Pharmacol. 2021,12:626735

Evolution of Nitrogen-Based Alkylating Anticancer Agents

Lehmann, F.; Wennerberg, J.
Processes 2021, 9, 377

An Aldehyde Responsive, Cleavable Linker for Glucose Responsive Insulins

Mannerstedt, K.; Mishra, N. M.; Engholm, E.; Lundh, M.; Madsen, C. S.; Pedersen, P. J.; Le-Huu, P.; Pedersen, S. L.; Buch-Månson, N.; Borgström, B.; Brimert, T.; Fink, L. N.; Fosgerau, K.; Vrang, N.; Jensen, K. J.
Chemistry, 2021, 1-12

Melflufen: A Journey from Discovery to Multi-Kilogram Production

Lehmann, F.; Wennerberg, J.
Complete Accounts of Integrated Drug Discovery and Development: Recent Examples from the Pharmaceutical Industry Volume 3, Chapter 5 pp 157-177, 2020

NMR Study of the Secondary Structure and Biopharmaceutical Formulation of an Active Branched Antimicrobial Peptide

Castiglia, F.; Zevolini, F.; Riolo, G.; Brunetti J, De Lazzari, A:, Moretto, A.; Manetto, G.; Fragai, M.; Algotsson, J.; Evenäs, J.; Bracci, L.; Pini, A.; Falciani, C.
Molecules 2019, 24(23), 4290-4302

Monosaccharide Derivatives with Low Nanomolecular Lectin Affinity and High Selectivity Based on Combined Fluorine-Amide, Phenyl-Arginine, Sulfur-π, and Halogen Bond Interactions

Zetterberg, F.; Peterson, K.; Johnsson, R.; Brimert, T.; Håkansson, M.; Logan. D.; Leffler, H.; Nilsson, U.
ChemMedChem. 2018;13(2):133–137

Structural Insights into the Calcium-Mediated Allosteric Transition in the C-Terminal Domain of Calmodulin from Nuclear Magnetic Resonance Measurement

Kukic, P.; Lundström, P.; Camilloni, C.; Evenäs, J.; Akke, M.; Vendruscolo, M.
Biochemistry 2016 Jan 12;55(1):19-28

Identification of indole inhibitors of human hematopoietic prostaglandin D2 synthase (hH-PGDS)

Edfeldt, F.; Evenäs, J.; Lepistö, M.; Ward, A.; Petersen, J.; Wissler, L.; Rohman, M.; Sivars, U.; Svensson, K:, Perry, M.; Feierberg, I:, Zhou, X.; Hansson, T.; Narjes, F.
Bioorg Med Chem Lett. 2015 15;25(12):2496-2500

HTS followed by NMR based counterscreening. Discovery and optimization of pyrimidones as reversible and competitive inhibitors of xanthine oxidase

Evenäs, J.; Edfeldt, F.; Lepistö, M.; Svitacheva, N.; Synnergren, A.; Lundquist, B.; Gränse, M.; Rönnholm, A.; Varga, M.; Wright, J.; Wei, M.; Yue, S.; Wang, J.; Li, C,; Li, X.; Chen, G:, Liao, Y.; Lv, G.; Tjörnebo, A.; Narjes, F.
Bioorg & Med Chem Lett. 2014, 24(5), 1315–1321