Publications

Monteiro, H.; Santos, F.; Paiva A.; Duarte, A. R. C.; Ferreira, R. J. Molecular Dynamics Studies of Therapeutic Liquid Mixtures and Their Binding to Mycobacteria. Front. Pharmacol. 2021,12:626735.
https://doi:10.3389/fphar.2021.626735

Lehmann, F.; Wennerberg, J. Evolution of Nitrogen-Based Alkylating Anticancer Agents. Processes 2021, 9, 377. https://doi.org/10.3390/pr9020377

Mannerstedt, K.; Mishra, N. M.; Engholm, E.; Lundh, M.; Madsen, C. S.; Pedersen, P. J.; Le-Huu, P.; Pedersen, S. L.; Buch-Månson, N.; Borgström, B.; Brimert, T.; Fink, L. N.; Fosgerau, K.; Vrang, N.; Jensen, K. J. An Aldehyde Responsive, Cleavable Linker for Glucose Responsive Insulins. Chemistry, 2021, 1-12. https://doi.org/10.1002/chem.202004878

Lehmann, F.; Wennerberg, J. Melflufen: A Journey from Discovery to Multi-Kilogram Production in Complete Accounts of Integrated Drug Discovery and Development: Recent Examples from the Pharmaceutical Industry Volume 3, Chapter 5 pp 157-177, 2020. https://doi:10.1021/bk-2020-1369.ch005

Castiglia, F.; Zevolini, F.; Riolo, G.; Brunetti J, De Lazzari, A:, Moretto, A.; Manetto, G.; Fragai, M.; Algotsson, J.; Evenäs, J.; Bracci, L.; Pini, A.; Falciani, C. NMR Study of the Secondary Structure and Biopharmaceutical Formulation of an Active Branched Antimicrobial Peptide. Molecules 2019, 24(23), 4290-4302.
https://doi.org/10.3390/molecules24234290

Zetterberg, F.; Peterson, K.; Johnsson, R.; Brimert, T.; Håkansson, M.; Logan. D.; Leffler, H.; Nilsson, U. Monosaccharide Derivatives with Low Nanomolecular Lectin
Affinity and High Selectivity Based on Combined Fluorine-Amide, Phenyl-Arginine,
Sulfur-π, and Halogen Bond Interactions. ChemMedChem. 2018;13(2):133–137.
https://doi.org/10.1002/cmdc.201700744

Kukic, P.; Lundström, P.; Camilloni, C.; Evenäs, J.; Akke, M.; Vendruscolo, M.
Structural Insights into the Calcium-Mediated Allosteric Transition in the C-Terminal Domain of Calmodulin from Nuclear Magnetic Resonance Measurement. Biochemistry 2016 Jan 12;55(1):19-28. https://doi.org/10.1021/acs.biochem.5b00961

Edfeldt, F.; Evenäs, J.; Lepistö, M.; Ward, A.; Petersen, J.; Wissler, L.; Rohman, M.; Sivars, U.; Svensson, K:, Perry, M.; Feierberg, I:, Zhou, X.; Hansson, T.; Narjes, F. Identification of indole inhibitors of human hematopoietic prostaglandin D2 synthase (hH-PGDS). Bioorg Med Chem Lett. 2015 15;25(12):2496-2500.
https://doi.org/10.1016/j.bmcl.2015.04.065

Evenäs, J.; Edfeldt, F.; Lepistö, M.; Svitacheva, N.; Synnergren, A.; Lundquist, B.; Gränse, M.; Rönnholm, A.; Varga, M.; Wright, J.; Wei, M.; Yue, S.; Wang, J.; Li, C,; Li, X.; Chen, G:, Liao, Y.; Lv, G.; Tjörnebo, A.; Narjes, F. HTS followed by NMR based counterscreening. Discovery and optimization of pyrimidones as reversible and competitive inhibitors of xanthine oxidase. Bioorg & Med Chem Lett. 2014, 24(5), 1315–1321. https://doi.org/10.1016/j.bmcl.2014.01.050

Lorem ipsum

Discovery of the Selective and Orally Available Galectin-1 Inhibitor GB1908 as a Potential Treatment for Lung Cancer

Zetterberg FR, Peterson K, Nilsson UJ, et al. Discovery of the Selective and Orally Available Galectin-1 Inhibitor GB1908 as a Potential Treatment for Lung Cancer. J Med Chem. Published online May 28, 2024. doi:10.1021/acs.jmedchem.4c00485

N-Butylpyrrolidinone is an equally good solvent as N,N-dimethylformamide for microwave assisted solid phase peptide synthesis

Öhlander A, Lüdtke C, Sahakjan A, Johnsson RE. N-Butylpyrrolidinone is an equally good solvent as N,N-dimethylformamide for microwave assisted solid phase peptide synthesis. J Pept Sci. Published online May 8, 2024. doi:10.1002/psc.3612

A practical and environmentally friendly protocol forsynthesis of α-deuterated carboxylic acids

Wennerberg J, Dreisch K. A practical and environmentally friendly protocol for synthesis of α-deuterated carboxylic acids. J Labelled Comp Radiopharm. 2023;66(4-6):138-144. doi:10.1002/jlcr.4021

RG100204, A Novel Aquaporin-9 Inhibitor, Reduces Septic Cardiomyopathy and Multiple Organ Failure in Murine Sepsis

Mohammad S, O'Riordan CE, Verra C, et al. RG100204, A Novel Aquaporin-9 Inhibitor, Reduces Septic Cardiomyopathy and Multiple Organ Failure in Murine Sepsis. Front Immunol. 2022;13:900906. Published 2022 Jun 14. doi:10.3389/fimmu.2022.900906

Sialic Acid Derivatives Inhibit SiaT Transporters and Delay Bacterial Growth

Bozzola T, Scalise M, Larsson CU, et al. Sialic Acid Derivatives Inhibit SiaT Transporters and Delay Bacterial Growth. ACS Chem Biol. 2022;17(7):1890-1900. doi:10.1021/acschembio.2c00321

Characterization of the Aquaporin-9 Inhibitor RG100204 In Vitro and in db/db Mice

Florio M, Engfors A, Gena P, et al. Characterization of the Aquaporin-9 Inhibitor RG100204 In Vitro and in db/db Mice. Cells. 2022;11(19):3118. Published 2022 Oct 4. doi:10.3390/cells11193118

Discovery and Optimization of the First Highly Effective and Orally Available Galectin-3 Inhibitors for Treatment of Fibrotic Disease.

Zetterberg FR, MacKinnon A, Brimert T, et al. Discovery and Optimization of the First Highly Effective and Orally Available Galectin-3 Inhibitors for Treatment of Fibrotic Disease. J Med Chem. 2022;65(19):12626-12638. doi:10.1021/acs.jmedchem.2c00660

Molecular Dynamics Studies of Therapeutic Liquid Mixtures and Their Binding to Mycobacteria

Monteiro H, Santos F, Paiva A, Duarte ARC, Ferreira RJ. Molecular Dynamics Studies of Therapeutic Liquid Mixtures and Their Binding to Mycobacteria. Front Pharmacol. 2021;12:626735. Published 2021 Apr 20. doi:10.3389/fphar.2021.626735

Evolution of Nitrogen-Based Alkylating Anticancer Agents

Lehmann F, Wennerberg J. Evolution of Nitrogen-Based Alkylating Anticancer Agents. Processes. 2021; 9(2):377. https://doi.org/10.3390/pr9020377

An Aldehyde Responsive, Cleavable Linker for Glucose Responsive Insulins

Mannerstedt K, Mishra NK, Engholm E, et al. An Aldehyde Responsive, Cleavable Linker for Glucose Responsive Insulins. Chemistry. 2021;27(9):3166-3176. doi:10.1002/chem.202004878

Melflufen: A Journey from Discovery to Multi-Kilogram Production

Lehmann F, Wennerberg J. Melflufen: A Journey from Discovery to Multi-Kilogram Production. ACS Symposium Series. Published online January 2020:157-177. doi:https://doi.org/10.1021/bk-2020-1369.ch005

NMR Study of the Secondary Structure and Biopharmaceutical Formulation of an Active Branched Antimicrobial Peptide

Castiglia F, Zevolini F, Riolo G, et al. NMR Study of the Secondary Structure and Biopharmaceutical Formulation of an Active Branched Antimicrobial Peptide. Molecules. 2019;24(23):4290. Published 2019 Nov 25. doi:10.3390/molecules24234290

Monosaccharide Derivatives with Low Nanomolecular Lectin Affinity and High Selectivity Based on Combined Fluorine-Amide, Phenyl-Arginine, Sulfur-π, and Halogen Bond Interactions

Zetterberg FR, Peterson K, Johnsson RE, et al. Monosaccharide Derivatives with Low-Nanomolar Lectin Affinity and High Selectivity Based on Combined Fluorine-Amide, Phenyl-Arginine, Sulfur-π, and Halogen Bond Interactions. ChemMedChem. 2018;13(2):133-137. doi:10.1002/cmdc.201700744

Structural Insights into the Calcium-Mediated Allosteric Transition in the C-Terminal Domain of Calmodulin from Nuclear Magnetic Resonance Measurement

Kukic P, Lundström P, Camilloni C, Evenäs J, Akke M, Vendruscolo M. Structural Insights into the Calcium-Mediated Allosteric Transition in the C-Terminal Domain of Calmodulin from Nuclear Magnetic Resonance Measurements. Biochemistry. 2016;55(1):19-28. doi:10.1021/acs.biochem.5b00961

Identification of indole inhibitors of human hematopoietic prostaglandin D2 synthase (hH-PGDS)

Edfeldt F, Evenäs J, Lepistö M, et al. Identification of indole inhibitors of human hematopoietic prostaglandin D2 synthase (hH-PGDS). Bioorg Med Chem Lett. 2015;25(12):2496-2500. doi:10.1016/j.bmcl.2015.04.065

HTS followed by NMR based counterscreening. Discovery and optimization of pyrimidones as reversible and competitive inhibitors of xanthine oxidase

Evenäs J, Edfeldt F, Lepistö M, et al. HTS followed by NMR based counterscreening. Discovery and optimization of pyrimidones as reversible and competitive inhibitors of xanthine oxidase. Bioorg Med Chem Lett. 2014;24(5):1315-1321. doi:10.1016/j.bmcl.2014.01.050