Drug Discovery Chemistry, Fragment-Based Drug Discovery Conference, San Diego, California
From Fragment Hit to Lead to Optimization to Small Molecule Drug Candidate
Cambridge Healthtech Institute’s 17th Annual
APRIL 19-20, 2022, San Diego, California
Red Glead Discovery are giving a talk at:
9.25 AM on the 19th: Exploring the Bromodomain of SMARCA4 (BRG1) by Weak Affinity Chromatography
Kirill Popov, PhD, Head of FBLD, Weak Affinity Chromatography WAC
The advantages of WAC for FBS are the detection of weak binders by screening fragments at low concentrations (<5 μM) and immediate ranking of hits. Here we present the results of a WAC screen towards SMARCA4 as well as subsequent hit validation and expansion efforts.